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DOI: 10.1160/TH04-04-0228
Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London
Financial support: The WHSS has received support from the former Wandsworth and South Thames Regional Health Authorities, NHS R & D Directorate, British Heart Foundation, former British Diabetic Association and The Stroke Association. Dr. Miller was supported by the British Heart Foundation (Project Grant PG/2001023), the IMMIDIET Project (EC QLK1-CT-2000-00100) and The Wellcome Trust VIP Award.
Publication History
Received
14 April 2004
Accepted after resubmission
27 July 2004
Publication Date:
04 December 2017 (online)
Summary
The aim was to investigate whether the Thr715Pro P-selectin polymorphism is associated with soluble P-selectin (sP-selectin) levels in individuals from different ethnic groups. Plasma sPselectin and Thr715Pro (A/C) P-selectin gene polymorphism were measured in 237 white (106 females), 177 black African origin (92 females) and 201 South Asian (94 females) individuals living in England. All were free from coronary heart disease (CHD), stroke and other cardiovascular disease, diabetes, drug therapy for hypertension or high lipids, hormone replacement therapy or oral contraceptive pill. The Thr715Pro C allele was rare in blacks (0.8%) and intermediate in South Asians (3.0%) compared to whites (11.2%; p <0.001). sP-selectin levels were significantly lower in the individuals with the AC or CC compared to the AA genotype in both whites (-25% (95% C.I. -33.3 to -16.9); p <0.001) and South Asians (-25.2% (-40.5 to -6.1); p <0.012). There was insufficient power for this analysis in blacks. In conclusion, in whites and South Asians the C allele of the Thr715Pro P-selectin polymorphism is associated with lower sP-selectin levels. Lower levels of sP-selectin were not accounted for by this polymorphism in blacks, in whom the C allele was very rare.
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